Researchers in Canada have carried out a research suggesting that novel Cannabis sativa extracts could lower ranges of the host cell receptor that extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) makes use of to achieve viral entry to focus on tissues.

Study: In search of preventive strategies: novel high-CBD Cannabis sativa extracts modulate ACE2 expression in COVID-19 gateway tissues. Image Credit: Dmytro Tyshchenko / Shutterstock

SARS-CoV-2 is the agent liable for the present coronavirus illness 2019 (COVID-19) pandemic that continues to brush the globe threatening public well being and the worldwide economic system.

The staff – from the University of Lethbridge and Pathway Rx Inc., Lethbridge – developed a whole bunch of recent C. sativa cultivars and examined 23 extracts in synthetic 3D human fashions of the oral, airway and intestinal tissues.

As lately reported within the journal Aging, 13 of the extracts downregulated expression of the SARS-CoV-2 host cell receptor angiotensin-converting enzyme 2 (ACE2).

“The observed down-regulation of ACE2 gene expression by several tested extracts of new C. sativa cultivars is a novel and crucial finding,” say the researchers.

“While our most effective extracts require further large-scale validation, our study is important for future analyses of the effects of medical cannabis on COVID-19,” write Olga Kovalchuk and colleagues.

Overview of the experimental models and setups. H&E-stained cross sections are a courtesy of MatTek Life Sciences.

Overview of the experimental fashions and setups. H&E-stained cross-sections are courtesy of MatTek Life Sciences.

“Down-regulation of ACE2 ranges in gateway tissues could also be…

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