It’s not unusual to search out cannabis customers who additionally use psychoactive mushrooms, and vice versa. The web is filled with articles about self-administering psilocybin and marijuana collectively, with anecdotal studies from individuals who understand an enhanced impact from the mixture.
What does the science say about how these two substances have an effect on the patron when taken collectively?
People have mixed the 2 compounds for a long time—if not centuries. One 2006 study that regarded into polysubstance use amongst college college students discovered that of the 149 college students surveyed, almost 60% commonly co-administered cannabis and psilocybin (the energetic ingredient in psychedelic mushrooms).
That co-administration remained largely restricted to the experimentation of youthful adults, although, till not too long ago. In the previous few years, mainstream curiosity in psilocybin has exploded, pushed by promising analysis into its therapeutic use.
That rising curiosity resulted in a historic vote in Oregon and Washington, DC, earlier this month, during which the state and the district each decriminalized the possession and use of psilocybin.
It will quickly be authorized to make use of each substances collectively in these jurisdictions. But is that a good concept? What does the science say about how these two substances have an effect on the patron when taken collectively? Here’s what we all know.
What are psychedelics?
Most of what we all know concerning the pairing comes from anecdotal studies. The expertise provoked by ingesting a psychedelic substance—not to mention the mixture of two totally different psychedelics like psilocybin and cannabis—is extremely subjective. It could be affected by a individual’s mindset and their social setting, sometimes called “set and setting.” This makes the consequences of those medicine troublesome to check in a managed manner.
That mentioned, cannabis can increase the impact of psilocybin, significantly when paired with a heroic dose of psilocybin.
Michelle Janikian, writer of Your Psilocybin Mushroom Companion, wrote about “What You Need to Know About Smoking Weed While Tripping” for Double Blind final 12 months. “The main concern,” she wrote, is the patron’s “mental and spiritual well-being, because cannabis can have an unpredictably strong effect when mixed with psychedelics.”
How to arrange for your first psychedelic mushroom journey
Intensifying the journey
It’s not unusual to listen to that cannabis intensified somebody’s expertise with heroic dose of psilocybin—and never essentially in a great way.
“I personally find mixing cannabis and mushrooms together can be a bit intense for me,” reported Janelle Lassalle, a Leafly contributor who writes concerning the psychedelic world at her web site, The Full Spectrum Revolution. “It depends on how I’ve been feeling, but if I’m not doing well emotionally and I’ve taken mushrooms, they’ll bring those thoughts to the forefront. This kind of volatile emotional state, then, doesn’t always mix well with larger doses of cannabis.”
Hallucinations may persist
A 2019 literature review revealed within the Journal of Addictive Diseases additionally talked about the elevated emotional depth talked about by Lassalle. Russian researchers famous a medical presentation of hallucinogen persisting notion dysfunction (HPPD), a situation characterised by recurrent hallucinations whereas on and off of drugs, in three topics who paired cannabis with psilocybin with further substances.
The topics described the experiences as “stressful and frightening.” That HPPD occasion was a single medical presentation, nonetheless, and never a widespread response present in a full medical examine—in different phrases, it’s a tiny pattern dimension and shouldn’t be taken as conclusive proof.
Cannabis with a microdose of psilocybin
Lassalle mentioned she typically finds mushrooms to be extra satisfying on their very own, however she and her associate sometimes use cannabis with micro-doses of psilocybin, which she says is way more satisfying—and well-liked, in accordance others who partake on this pairing.
“A microdose with cannabis feels like you’re having a wonderful day, plain and simple,” mentioned Lasalle. “I have higher energy levels, but not at a racy level. I’m more alert, focused, creative. I can fall asleep more easily at the end of the night. Colors look a little brighter and everything feels more vivid.”
Is it protected to pair cannabis and psilocybin?
According to a 2017 report by the Global Drug Survey, psilocybin sends the fewest folks to the emergency room of any drug in the marketplace. “Perhaps the most dangerous thing about psychedelic mushrooms,” famous Popular Science, “is that they’re easily confused for the poisonous kind.”
Cannabis has a well-known observe document with regard to lethality: No one has ever died from a marijuana overdose. It merely doesn’t have an effect on the mind and physique in the identical manner as opioids and different probably lethal medicine.
Is lack of bad information… excellent news?
Dr. Evan Wood is a doctor and epidemiologist who’s spent most of his profession finding out substance use clinically. Many sufferers in his personal medical apply have used psilocybin and cannabis. But there are few revealed research on the mixed results of utilizing each compounds collectively.
“I think the one thing that can be inferred from the lack of studies is probably that [taking the two compounds together is] not remotely toxic, because we know that cannabis isn’t particularly toxic on its own, and neither is psilocybin,” Wood instructed Leafly.
“If you look at ibogaine for instance, a lot of literature exists that stems from the toxicology literature,” he added. “So that’s just from people doing it in the community and showing up in hospitals and poison control centers, or investigators doing research, studying these effects. So, if there was a toxic, synergistic effect of cannabis and psilocybin, we would know about it.”
Can this pairing have therapeutic advantages?
While many individuals use psychedelics purely for the expertise, some are pairing psilocybin and cannabis for potential well being advantages. The reported success of psychedelic-assisted therapies is so compelling that specialists mission psychedelics will someday pose a menace to the booming market for anti-depressants and different pharmaceutical medicine.
Likewise, cannabis—significantly CBD—has turn out to be a well-liked different to conventional prescription drugs, particularly for pain relief.
A fan of each substances, however not collectively
Ophelia Chong, a longtime cannabis entrepreneur, mentioned she incessantly micro-doses psilocybin for its “world-changing” psychological well being results. But Chong retains the 2 substances separate. She instructed Leafly she believes that the introduction of cannabis would seemingly take away from the good thing about psilocybin.
“It’s like a car and a horse,” Chong mentioned. “Psilocybin and cannabis are two different things. If you’re going to do psilocybin, I would do it first to experience the journey and really answer the questions you want. Then add cannabis later to come down—because cannabis, I believe, mutes a lot of your questions.” Using cannabis on prime of psilocybin, she added, “is putting blinders on when you should have them off.”
Using cannabis for a tender touchdown
Evan Wood confirmed that he’s heard of sufferers utilizing cannabis on the latter finish of a psilocybin journey, to facilitate a tender comedown from the energizing results of psilocybin. “I think we know from just use in a naturalistic context of psychedelic substances people commonly use cannabis alongside different drugs including psychedelics, and at least anecdotally people will commonly use cannabis to support the come-down or to synergistically augment the experience,” mentioned Wood.
Though some customers discover the advantages of psilocybin and cannabis are higher reaped individually, anecdotal studies from others declare that utilizing the medicine in tandem has been a key to their well being and wellness.
“I have never consumed mushrooms without cannabis,” mentioned one shopper who spoke to Leafly however requested to stay nameless as a result of the authorized standing of the substances. “I consider mushrooms [to be] cannabis’ older bigger brother, which complete my medicinal needs. Cannabis for physical ailments. Mushrooms for my soul. The combination being the apex of healing.”
Could co-administration enhance therapeutic results?
It’s unclear precisely if or how cannabis and psilocybin could be taken collectively to enhance therapeutic advantages. Nonetheless, Evan Wood is keen to know this synergy, particularly as a result of drug synergies are widespread and sometimes leveraged to enhance a affected person’s general well being.
“From my perspective as an internal medicine physician it’s very common for two medications to be included together for synergistic effects,” mentioned Wood. “I see patients all the time who are on a combination ACE inhibitor diuretic pill for their high blood pressure. You don’t want to give too much diuretic or someone’s electrolytes might go out of whack. But we can give some diuretic and we can give some ACE inhibitor and we can get this great synergistic effect on blood pressure.”
“I think we know [taking psilocybin and cannabis together] appears to be safe. I think we know that it’s happening naturalistically in the community and probably has been for centuries. As we go into the modern era, we’d be silly to put blinders on and ignore the fact that these types of things are going to occur—and we should be exploring what it means.”
More analysis is underway
Wood isn’t alone on this pondering. The University of Miami medical faculty simply received funding from a Toronto-based firm, Tassili, to check the consequences of mixing psilocybin and CBD in treating traumatic mind accidents and PTSD. Researchers marvel if the entourage impact—the synergistic interaction between the various cannabinoids and terpenes present in cannabis—may additionally occur when CBD is paired with psilocybin.
That University of Miami examine will enter a human medical trial part in early 2021. If the 2 compounds are discovered to work effectively collectively, they could supply aid to army veterans that suffer disproportionately from traumatic mind accidents and PTSD.
Dr. Michael Hoffer, the chief scientist main the examine, mentioned: “Our goal is to develop a prescription pill with these ingredients that treat mTBI [mild traumatic brain injury] and PTSD. This is a new and increasingly exciting area.”