The authors investigated the indications for cannabis prescription in the Netherlands and assessed its efficacy and negative effects. A majority (64.1%) of sufferers reported a very good or wonderful impact on their signs. Of these sufferers, roughly 44% used cannabis for >/=5 months. Indications have been neurologic problems, ache, musculoskeletal problems, and most cancers anorexia/cachexia. Inhaled cannabis was perceived as simpler than oral administration. Reported negative effects have been usually gentle.