Last fall, Dr. Raphael Mechoulam, the Israeli innovator often known as the “Godfather of cannabis research,” introduced the creation of cannabidiolic acid methyl ester (EPM301), a artificial cannabinoid that’s much more potent than THC or CBD. Now, after a number of months of testing, researchers have discovered that this new compound may very well be a highly effective remedy for nausea, anxiousness, and inflammatory problems.
EPM301, which was developed and patented by Dr. Mechoulam and a workforce of researchers from US-based biotech agency EPM, is a artificial model of a pure acid that happens inside the hashish plant. In addition to hashish compounds like THC, CBD, and terpenes, dwelling hashish crops comprise a selection of acids, equivalent to THC-A or CBD-A. These acids are much more potent than their extra well-known counterparts, however they’re additionally extremely unstable.
For years, this instability has prevented researchers from efficiently isolating these acids from dwelling crops and utilizing them for medicinal functions. But final September, Dr. Mechoulam and EPM introduced that they’d found out a technique to modify these acids to make them steady. To accomplish this feat, researchers used a course of referred to as esterification, wherein two separate chemical compounds mix to kind a steady compound referred to as an ester.
“EPM developed a method to work with the original substances of cannabis,” defined Dr. Mechoulam to Forbes. “So, while everybody is discussing THC and CBD, these cannabinoids are actually a secondary substance; they only appear later in the plant. Originally there is an acid that appears in the plant, and those acids are these mysterious worlds of compounds that are much more potent than cannabinoids.”
Over the previous a number of months, EPM has began exploring the therapeutic potential of this new compound. Preliminary research have discovered that EPM301 can successfully suppress anxiousness in addition to nausea, with out inflicting any destructive negative effects. These findings counsel that the brand new compound may very well be used to deal with chemotherapy-induced nausea or problems like psoriasis or inflammatory bowel illness (IBD).
“We badly need new drugs in several diseases and some of the drugs that are available, may be pretty good but they ultimately cause side effects,” Dr. Mechoulam told Forbes. “We have two groups of compounds today that need to have a replacement: these are steroids and opioids. We believe that cannabis carries the ability to introduce replacements to these families.”
“We compare our compound not only to cannabinoids, but to the existing drugs that are applied today,” the physician continued. “So, for example, in IBD we compared our compounds to two conventional products: one is the prednisone (the steroids) and one is a biological drug. And in both of them, we managed to prove that the activity of our compound is very similar to the common one.”
This new discovery is barely the most recent spark of inspiration in Dr. Mechoulam’s lengthy profession of hashish analysis. In the early 1960s, the physician was the primary to find cannabinoids like THC and CBD. Since then, Dr. Mechoulam has made dozens of different discoveries within the discipline, and even now, on the age of 88, the physician continues in his quest to search out new purposes for this highly effective, medicinal plant.