Recent publicity to marijuana isn’t related to an elevated danger of ischemic stroke. This is in line with a brand new examine printed within the journal Neurology: Clinical Practice. The examine is titled Association between current cannabinoid use and acute ischemic stroke.

For the examine researchers with the University of Mississippi, Department of Neurology examined whether or not or not these testing optimistic for marijuana throughout a hospital admission display screen have been extra prone to undergo from an acute ischemic stroke as in comparison with those that examined unfavourable. According to NORML, who first reported on the examine, researchers recognized no hyperlink between current hashish publicity and both an elevated or decreased danger of stroke after adjusting for confounders equivalent to age, hypertension, and excessive ldl cholesterol.

They concluded: “Studies that have analyzed the association between cannabis use and acute ischemic stroke have provided conflicting results. … This is one of the few studies analyzing the association of recent cannabis use and acute ischemic stroke using admission urine toxicology test independent of polysubstance use. Even though our study has limitations, we did not find an independent association between recent cannabis use and the incidence of acute ischemic stroke. Further studies utilizing urine toxicology tests with larger sample size and including dosage of cannabis exposure should be done.”

According to NORML “The findings are inconsistent with those of a 2019 study published in the International Journal of Stroke which reported a higher risk of younger-onset stroke-related hospitalization among those who with a history of cannabis use. NORML has long cautioned that those with a history of cardiovascular disease may be at greater potential risk for adverse events from cannabis exposure.”

The full summary of the examine will be discovered under:

Objective: Studies which have analyzed the affiliation between hashish use and acute ischemic stroke have supplied conflicting outcomes. In this examine, we purpose to find out the affiliation of current hashish use detected by urine drug display screen amongst sufferers admitted with acute ischemic stroke.

Methods: A retrospective observational examine was carried out using the medical data database. All sufferers 18 years and older admitted from January 1, 2015 to December 31, 2017 who underwent urine toxicology testing on admission have been included within the evaluation. Multivariate logistic regression evaluation was performed to investigate unbiased affiliation between current hashish use and acute ischemic stroke.

Results: A complete of 9,350 sufferers have been decided to have undergone urine drug display screen throughout admission and 18% (1,643) of this had a optimistic urine hashish take a look at. Unadjusted danger ratio confirmed a 50% lower in danger of acute ischemic stroke amongst hashish customers (RR = 0.505, 95% CI 0.425 – 0.600). The impact was misplaced after adjusting for age, race, ethnicity, sickle cell illness, dyslipidemia, hypertension, weight problems, diabetes mellitus, cigarette smoking, atrial fibrillation, and different cardiac situations (OR 1.038, 95% CI 0.773-1.394).

Conclusion: This is without doubt one of the few research analyzing the affiliation of current hashish use and acute ischemic stroke utilizing admission urine toxicology take a look at unbiased of polysubstance use. Even although our examine has limitations, we didn’t discover an unbiased affiliation between current hashish use and the incidence of acute ischemic stroke. Further research using urine toxicology assessments with bigger pattern measurement and together with dosage of hashish publicity ought to be performed.

Source link