Seems lots of people are caught within the “stoners are idiots” and “indica vs sativa” discussions, et al, so it then appeared like a good suggestion to only go forward and publish some info for folks to overview.

As at all times, when it is advisable discover authoritative sources for info/strategies on restricted subjects, effectively, erowid.org has been round longer than dancesafe.org however they’ve each been round a LONG time and are effectively revered sources for what folks use them for.

There are additionally a number of YouTube channels that show the right way to check your medicine and the place you possibly can see what occurs in actual life when folks do them if you’re questioning what it is like and do not wish to simply go forward and do them (now I’m bordering on waxing political, so on to the data!)

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Endocannabinoid system

From Wikipedia, the free encyclopedia

The endocannabinoid system (ECS) is a organic system composed of endocannabinoids, that are endogenous lipid-based retrograde neurotransmitters that bind to cannabinoid receptors (CBRs), and cannabinoid receptor proteins which might be expressed all through the vertebrate central nervous system (together with the mind) and peripheral nervous system. The endocannabinoid system stays underneath preliminary analysis, however could also be concerned in regulating physiological and cognitive processes, together with fertility,[1] being pregnant,[2] throughout pre- and postnatal improvement,[3] varied exercise of immune system,[4] urge for food, pain-sensation, temper, and reminiscence, and in mediating the pharmacological results of hashish.[5][6]

https://en.wikipedia.org/wiki/Endocannabinoid_system

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Abstract

The latest identification of cannabinoid receptors and their endogenous lipid ligands has triggered an exponential development of research exploring the endocannabinoid system and its regulatory features in well being and illness. Such research have been drastically facilitated by the introduction of selective cannabinoid receptor antagonists and inhibitors of endocannabinoid metabolism and transport, in addition to mice poor in cannabinoid receptors or the endocannabinoid-degrading enzyme fatty acid amidohydrolase.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241751/

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The authorities HAD a patent till final 12 months.

Cannabinoids as antioxidants and neuroprotectants

Abstract

Cannabinoids have been discovered to have antioxidant properties, unrelated to NMDA receptor antagonism. This new discovered property makes cannabinoids helpful within the remedy and prophylaxis of extensive number of oxidation related illnesses, akin to ischemic, age-related, inflammatory and autoimmune illnesses. The cannabinoids are discovered to have explicit software as neuroprotectants, for instance in limiting neurological injury following ischemic insults, akin to stroke and trauma, or within the remedy of neurodegenerative illnesses, akin to Alzheimer’s illness, Parkinson’s illness and HIV dementia.

https://patents.google.com/patent/US6630507B1/en

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Research

The Endocannabinoid System, Our Universal Regulator

June 1, 2018

Access PDF

AUTHORS: CHAD A. SALLABERRY AND LAURIE ASTERN

Institutions: Department of Biochemistry and Molecular Biology, Colorado State University, 111 MRB Building, Fort Collins, CO 80523

Nova Southeastern University, 3301 College Ave, Fort Lauderdale, FL 33314

ABSTRACT

The endocannabinoid system (ECS) performs an important function within the human physique for our survival. This is because of its capability to play a essential function in sustaining the homeostasis of the human physique, which encompasses the mind, endocrine, and immune system, to call a couple of. ECS is a novel system in a number of dimensions. To start with, it’s a retrograde system functioning post- to pre-synapse, permitting it to be a “master regulator” within the physique. Secondly, it has a really extensive scope of affect as a result of an abundance of cannabinoid receptors situated wherever from immune cells to neurons. Finally, cannabinoids are quickly synthesized and degraded, so they don’t keep within the physique for very lengthy in excessive quantities […] This paper will talk about how ECS features by means of the regulation of neurotransmitter operate, apoptosis, mitochondrial operate, and ion-gated channels. The sensible functions of the ECS, in addition to the avenues for illnesses akin to epilepsy, most cancers, amyotrophic lateral sclerosis (ALS), and autism, which haven’t any recognized remedy as of now, shall be explored.

https://www.jyi.org/2018-june/2018/6/1/the-endocannabinoid-system-our-universal-regulator

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The Science of the Endocannabinoid System: How THC Affects the Brain and the Body

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First revealed 2011

After a number of a long time of analysis, scientists finding out the consequences of marijuana made a number of vital discoveries. Not solely did they determine the lively ingredient in marijuana, additionally they found the place and the way it works within the mind—by way of a brand new system they known as the endocannabinoid (EC) system. The EC system—named after the marijuana plant Cannabis sativa and its lively ingredient delta-9-tetrahydrocannabinol (THC)—is a novel communications system within the mind and physique that impacts many vital features, together with how an individual feels, strikes, and reacts.

The pure chemical substances produced by the physique that work together inside the EC system are known as cannabinoids, and like THC, they work together with receptors to manage these vital physique features. So what makes the EC system distinctive and the way does THC’s impression on this method have an effect on an individual’s reminiscence, threat for accidents, and even habit?

http://headsup.scholastic.com/students/endocannabinoid

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Endocannabinoids

Endocannabinoids (ECs) are outlined because the endogenous ligands of cannabinoid receptors (CB1 and CB2) and a rising physique of proof has emerged on the function of the endocannabinoid system (ECS) within the regulation of a number of physiological circumstances and quite a few illnesses.

From: The Endocannabinoidome, 2015

https://www.sciencedirect.com/topics/neuroscience/endocannabinoids

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